Translational and Clinical

Journey of a Molecular Detective; David Sherratt

Translational and Clinical Medicine is the ongoing effort to bring basic science from the bench to the patient, as well as to elucidate safety and effectiveness of the medicines on which we depend. The NDM podcasts on translational and clinical medicine detail our work in this wide-ranging field, from the identification and design of new medicines to clinical trials and trial design and regulation.

Nuffield Department of Clinical Medicine

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Displaying 1 - 23 of 23 episodes

Episode	Description	People	Date
Tracking infections	Professor Derrick Crook from our Experimental Medicine division tells us about his research on tracking infections	Derrick Crook	8 February, 2017
Why we work on Alzheimer’s disease	Housed within the Target Discovery Institute, the Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) juxtaposes drug discovery expertise alongside scientific and academic understanding of patients, disease mechanisms and model systems.	John Davis	30 November, 2016
X-rays for drug discovery	Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins.	Frank von Delft	23 September, 2016
From information to structure	Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data.	Brian Marsden	2 June, 2016
Unravelling proteins	Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies.	Nicola Burgess-Brown	28 April, 2016
Targeting drug discovery	The development of new medicines is dependent on the identification of novel drug targets.	Kilian Huber	28 April, 2016
Understanding growth signals	Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection.	Alex Bullock	27 April, 2016
Inflammation in disease	The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases.	Luzheng Xue	7 January, 2016
A deep breath in	Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people.	Mona Bafadhel	28 July, 2015
Chemistry, epigenetics and drugs	Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug.	Paul Brennan	28 July, 2015
The genetics of metabolic diseases	A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function.	Wyatt Yue	28 July, 2015
Biological imaging	Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data.	Jens Rittscher	9 February, 2015
Pharmacogenomics	Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions.	Sebastian Nijman	9 February, 2015
SHARP	Lowering cholesterol in chronic kidney disease	Colin Baigent	10 December, 2014
Wider Statin Use Saves Lives	Wider Statin Use Saves Lives	Colin Baigent	10 December, 2014
Asthma	Airway inflammation	Ian Pavord	10 December, 2014
The Global Health Network	Dr Trudie Lang tells us how the Global Health Network facilitates collaboration and resource sharing.	Trudie Lang	26 June, 2013
Respiratory Medicine	Dr Najib Rahman talks about his research on respiratory medicine.	Najib Rahman	28 May, 2013
Development of chemical probes	Professor Stefan Knapp tells us how the development of chemical probes helps us to find new drugs.	Stefan Knapp	21 May, 2013
Membrane proteins and drug development	Dr Liz Carpenter talks about her research on membrane proteins and drug development.	Liz Carpenter	29 April, 2013
Clinical Trials in Gastroenterology	Dr Simon Travis tells us how clinical trials bring tomorrow's treatments to patients today.	Simon Travis	25 March, 2013
Proteomics and Biomarkers	Dr Benedikt Kessler tells us how proteomics helps find biomarkers.	Benedikt Kessler	7 June, 2011
Drug Discovery	Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders.	Chas Bountra	20 December, 2010

Translational and Clinical

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